There’s not really any limits for content anymore. Look at Amazon’s The Boys.

The way you play Fallout / Skyrim / Bethesda games might end up being a perfect format for a television adaption.

You can have a main character and follow their travels in a really strange setting. You can have 1 off episodes with perticular styles much like the quests in the game. You can easily switch from a dark horror filled vault to a campy town the next episode. Kind of like the files would have lighter episodes then some really dark ones and occasionally an episode about the main characters.

Because the fallout universe has a lot to be explored you a smart writing team could do a lot.

TL;DR Gimme Twilight Zone in the wasteland