I did fallout 4 and it worked. Skyrim should be mostly the same and most Bethesda games have packs that claim better looks and performance. I used steam tinker launch to install mod organizer 2 to the prefix. You could do vortex the same way. I also toggled case sensitivity for the prefix folder in case of weird mod behavior, probably not necessary but it can only be toggled on empty folders, so before install or delete and reinstall, and if you haven’t used the btrfs mod.