Honestly it really changes with my mood. If I'm planning on an insanity run the mods have more to do with mechanics than anything else. If I'm in a story mood I'll get some really great hair and outfits xD

When Legendary edition came out they redid basically everything, so the slate was wiped; but I'm gearing up for another run as soon as I get my PC back from the shop so if you wanna just tell me what kind of run you want I'll share my intel with you.

Leastways there have been some recent articles about the best new mods and unfortunately there's no Steam Workshop for them, so you'll need to head over to NexusMods to get the job done. Since that's also the main depository for the mods, you can also just pull up a list there and see what tickles your fancy.

https://www.youtube.com/watch?v=wvnZoGvTU54 for a comprehensive look at recent mods