Bottles is really just a really nice UI for managing wine/proton. If you already know what you want/need to run something, it’s a breeze to set up in bottles. And even if you don’t, trying the various tricks that exist to get something running is made easy.

I can’t say the same for lutris. It can do all the same things and even more, I just don’t like the UI/UX, at all. It can do tons, but IMO it’s not the best tool for any of it.

On bottles, the more you actually understand about how wine/proton can be configured, the more sense bottles will make.