It is looking more and more like it is Bluetooth related. After my initial post I discovered I could click on the Bluetooth icon and then navigate using my keyboard to the on/off slider. Once I restarted Bluetooth and reconnected my devices I could click again.

Yesterday I stopped by work (been home sick since Thursday) and grabbed my usb keyboard and trackball, since connecting them (they are what I use at work with my Steam deck) I have had no issues with clicks.